Hello @anthony.bencomo. There’s no real benefit in going above 48000 Hz when using Plug-Ins/Applications that include oversampling features since this tool will take care of any potential aliasing artifacts. Setting your sample rate to 88kHz or above will hurt your system performance in vain. You can check this video for more information about the subject.
Your system should be perfectly capable of running several instances of the Plug-In without any dropouts, as well as using the standalone application while playing Youtube videos. Be sure that you select “ASIO” at audio device type in the audio settings, and check that your sample rate matches the configuration of your system. Take a look at our guide for PC optimization if you haven’t already: Optimizing your PC for Music Production
If everything looks good on your system but you still experience crackling noises, analyze the stability of your PC using Latencymon. DPC latency can cause audio dropouts and it’s not always measured by CPU usage.
Remember that you can send screenshots/clips to support@neuraldsp.com if you need further assistance.