I plan to use quad cortex on a large stage and in a live environment. In that case, can I output directly through the mixer-PA? Of course, if the mixer has channels such as keyboard and vocals, and these are integrated and output to the PA, is it okay to output the quad cortex directly to the PA? In that case, should the tone that conflicts with the keyboard sound be overcome through EQ? Do you have any other tips?
Of course you can. This is a very common method. Assuming that you are using your QC for guitar…as long as you are using a cab model or IR and a good PA (and sound engineer), it should sound fantastic through the PA. How will you be monitoring your guitar on stage (FRFR cabinet(S), IEMs, stage monitor)?
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With our band, I’m sending outputs 3&4 to the board (using two TRS to XLR adapters) and sending outputs 1&2 to a pair of FRFR cabinets behind me. I have the volume knob assigned to outputs 1&2, only, so I can adjust my on-stage volume without altering the level feeding the board. You may need to adjust the level of the outputs feeding the board, depending on whether you are going into mic inputs or line inputs.
I go direct to board. I haven’t had an amp on stage in over 10 years. My only monitoring (for whole mix) is from a ZLX12P that sits in front of me. It’s not as great as moving air behind me or feeling the massive rumble on stage, but it allows the FOH mix to be VERY good. So yes, you can (should?) go direct to board 
Another direct to PA advocate here with many years of experience doing it. Modelers are made for it! I have had occasions where I was using a modeler but had to mic my stage monitor instead of going direct, and I always end up preferring the direct to board approach.
Most sound engineers grow to love it too. Consistent levels for them (if you gain-stage presets properly), no ambient and cumulative stage noise being picked up by potentially multiple instrument microphones, no positioning of guitar mic required. What’s not to like?
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