I’ve been using an iPad in my live rig for a couple years now. My main usage is SWAM sax/trumpet for certain horn leads, and various synth patches.
I run it in an effects loop, routing clean guitar into then straight out of the modeler outputs. No further processing in my Kemper/QC. It’s straight-pass through. If I want effects on the synths and stuff, I can add it via the iPad.
I use an iRig interface. The main consideration is bus powered or external powered. If I’m just fucking around, I use an iRig HD, which is powered off the USB port: no need for external power, but you can’t charge the iPad at the same time. It also has a replaceable chord.
For the stage, I use an iRig I/O which has a power adapter that will charge the iPad. However, this thing has the shittiest cable ever made. The end literally falls off, and you can’t use any off-the-shelf replacement. I’ve had them break at multiple gigs, just by being jostled. They charge $30 for a replacement. It’s a fucking racket. I ended up buying a stack of TC Helicon Go (Behringer’s clone) to have backups.
For software, it’s about AUM, which is a slick, deeply configurable iOS AU3 host. Hosting GUITAR 2 MIDI is necessary to reduce the buffer size (and thus latency), something G2M doesn’t support natively. I use two instances of GUITAR 2 MIDI, one set to monophonic and one set to polyphonic. My switching is configured to enable the correct one for the virtual instrument I want to play. You bypass instruments that aren’t in use, and they use no CPU.
I control the whole thing with a Blueboard, a tiny, wireless Bluetooth MIDI pedal with 4 buttons. It gets about a year on 4 AA batteries. I wrote a script in Mosaic, a programmable MIDI manipulation tool, also hosted in AUM, which lets me get 8 buttons out of my Blueboard: 4 patches on a single click, and 4 more patches on a double-click. This also gives me a visual of what patch I have selected.
I have two expression pedals on stage with my guitar rig. One of them uses a Y cable so that one expression pedal controls both my guitar rig (wah) and my synth rig (saxophone expression, synth cutoff, etc.)