The ability to assign global actions to rotary encoders, for example, the headphone volume would be very convenient to assign to the upper encoder responsible for switching preset banks (It seems to me that things like various volume controllers should always have physical manifestations available instantly, this is very important when working with sound).
Given that any effect parameters can be adjusted using the touch screen, we can freely use encoders for other tasks globally, for example, for MIDI commands, or the most popular parameters of amplifiers and effects that you always want to have at hand.