Title says it all, there is no dedicated direct Monitor off Function, and the level regulation does only affect Outputs L and R, but not the Monitoring on the Headphone.
Not sure if I really understood what you’re looking for, but if you put the Nano in tuner mode when using it as an audio interface, you will only hear the sound from your daw and not from the nano itself.
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Tuner mutes the processed USB signal, but leaves the DI Input to DAW through. I meant a way to mute the Output to Headphones from the Nano itself but still send DI AND processed Signal to the DAW Inputs. According to Neural DSP support there is no way yet to do that.