Volume knob, can it be assigned

I’m wondering if I can assign the volume knob to out 1/2 and have it not affect out 3/4. My QC just arrived today, so I’m looking forward to jumping in.

Nope, not possible (yet). The volume knob is global for all outputs.
You can adjust the outputs separately in the i/o menu. Swipe down from the top of the screen to access it.