You would need a way for Quad Cortex to support USB audio interfaces. AKAI Force has something like that which gets you 24 channels of digital I/O that then can be interfaced for example through ADAT to your RME card.
Can we get some votes for this feature maybe that will set things in motion? It’s technically definitely possible.
https://unity.neuraldsp.com/t/support-usb-audio-interfaces/11475