Quad Capture for use with a Chapman Stick

I play a chapman stick, which for those not aware, is a 10 or 12 string instrument, with two sets of audio output (melody and bass). If I run my melody side through input 1, and bass through input 2, will it be able to do completely different chains on each side (so one “patch” on one input, and a completely different one on the second? Any limitations with this?

Not necessarily separate presets for each but you can definitely have a separate signal chain for each.

Yes, that’s what I meant to say. Separate signal chains/effects for each input.

I presume with it being variable impedance, it’ll be able to handle both passive and active pickups well?

Variable impedance only makes a difference with passive pickups. Active pickups aren’t particularly affected by input impedance.