Mulitple questions on hooking up a quad to a powered P/A with DSP modes for Modelers

So my set up is guitar into the quad cortex, TRS cable through output 3/4 into a electrovoice ZLX 15P G2. I mention this specifically because someone might have experience with this model. But in general I think this would apply to any powered PA with DSP modes to be a do it all powered speaker.

So I have the option of flat frequency response on both the input as well as and mode in the main output section of the unit to select it for flat frequency response.

But here is the catch. From all my research the quad cortex is considered a line level device. And on the input section there is also an option for line input. There is more low end when set to Flat.

Im just trying to know what the most accurate way to do this would be. I know its kinda a trust your ears thing and do what sounds best. But I kinda want to set up the PA the way you would if it was just a plug straight in FRFR cab to get the truest sound of the quad and then adjust the levels of all my presets so I dont have to touch anything but the main volume on the quad to get the overall loudness I want.

I think what is frustrating me is that all of the different modes these things have change the way they behave and sound. But I use it as a monitor so the position setting i have as a floor monitor. That just makes sense. But its really the input setting that is getting me mixed up.

So if it was you, would you choose a FLAT input setting or a LINE input setting. And im told it is still ok to run a TRS cable even if your are running it mono to a single source. If that is incorrect please scold with fire in the comments.