Plugin into FRFR cab issue

Apologies if this has been ‘solved’ previously somewhere else but this is driving me up the wall.

I cannot get any sound from ANY plugin (Neural or otherwise) out of my FRFR cab. Set up is pretty simple - guitar in Behringer UMC22, the output (L) into a Laney LFR212. I can hear the DI signal of the guitar and likewise and I can hear the audio from YouTube through the speaker as well, so I know the guitar, cable and interface and speaker are working. Ive been playing the QC through the cab up until a few days ago as well.

I have tried every combination of input/outputs in the Plini plugin and checked all the obvious pitfalls. Still nothing. I’ve used Studio monitors with the same plugin previously so I dont think its a software issue.

Any ideas?