Leveling the output across all preset

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Best Practices for managing Output Levels?

My me-made presets’ output levels are all over the place. I play through headphones 100% of the time and like the big volume knob at 50. Where should I be leveling the output? It seems obvious to go for the Multi-Out, but that doesn’t seem right, like I should be setting the amp section first, then etc…(?) For example: my active strat goes into Input1 at about -20db when I pound on the strings. This goes into a simple preset: Jewel Comp (comp @3, all else stock), Captain 50 (stock), Zila Open …