Help my overdrive pedals sound awful

Need a bit of advice. I’m having trouble getting a good overdrive sound from my pedals through the QC. It’s more of an issue with single coils. I usually have a jewel compressor at the start of the chain then the amp, reverb or delay. The pedals run into the Qc as you would on a normal amp.
For me it sounds like the overdrive and clean sounds are separate if that makes sense. This is something I don’t get with humbuckere. Would anyone have any advice?