Four monitoring, out 1/2 for processed signal, out 3/4 for PC multimedia but

I would like to use QC as a sound card and output 1/2 for monitoring the processed signal, and output 3/4 for only PC sounds, such as YouTube, Spotify, Netflix, etc.

The problem is that all preset output settings are configured as Multiple Outputs, and the processed signal is mixing with output 3/4. I wonder if I can edit all presets to set the output as 1/2 at once?

I’m looking for a simple method that you can understand, and I’m waiting for your suggestions.