Yes I experimented different amps. I recently use US SPR (fender) for clean and Friedman for drive. There is recognizable gap while changing amps in a row. I tried them even with Friedman clean and rhythm models together. I admit QC is fast on switching, maybe the fastest in the market. However, whatever we do, if we bypass and engage different amps at the same time there is a tine drop which may be totally eliminated thanks to automated splitter line levels.