Can I output computer usb audio to output 3/4?

i.e. using 1/4 inch to monitors?
I can’t seem to get any computer audio such as youtube (not DAW audio) output using Out 3 / Out 4.
Thanks.

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Following,

Also keen for this as I don’t have XLR outputs for my monitors.

Hi. also looking for info on this. Sorry if its been discussed in another thread.